A、Marfan syndrome is due to mutations in the gene encoding fibrillin-1, a major constituent of microfibrils.
B、All cases of Ehlers–Danlos syndrome are due to mutations affecting the genes encoding the various types of collagen.
C、Laminin is found in renal glomeruli along with entactin, type IV collagen, and heparin or heparan sulfate.
D、Mutations affecting type IV collagen can cause serious renal disease.
E、Mutations in the collagen 1A1 gene can cause osteogenesis imperfecta.